The objective of present study was to formulate deflocculated and flocculated suspensions of metronidazole benzoate and evaluate various parameters of suspensions. Six deflocculated suspension formulations D1 to D6 were prepared having common humectants, preservatives 1 and 2, sweetener, pH adjusting agent and purified water. Among all six, one different in wetting agent, two differed in flocculating agents, one differed in complexing agent. There were two flocculating agents; one differed in concentration of 0.02% w/v to 0.1% w/v for two separate formulations. Seven flocculated suspension formulations (F1 to F7) were prepared in which wetting agent and flocculating agent were common to all but flocculating agent different in three concentration 0.02% w/v, 0.05 5 w/v and 0.1 w/v for three separate formulations. Viscosity enhancers and one complexing agent were used and they different not in all formulations but in some of formulations. Humectants, preservatives 1 and 2 sweetener, pH adjusting agent and purified water were common to all seven formulations. 100 g of metronidazole benzoate was suspended in 250 ml of volume in all 13 formulations. After evaluation of particle size distribution, sedimentation volume, degree of flocculation, resuspendability, drainage/ adherence test, photo-microscope study and assay, it was found that formulation with 0.05% flocculating agent is successful.
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